Publications archive

  • Craig L. Duvall, W. Robert Taylor, Daiana Weiss, and Robert E. Guldberg
    Quantitative microcomputed tomography analysis of collateral vessel development after ischemic injury
    Am J Physiol Heart Circ Physiol 287: H302-H310, 2004.
  • Lukas Kenner, Astrid Hoebertz, Timo Beil, Niamh Keon, Florian Karreth, Robert Eferl, Harald Scheuch, Agnieszka Szremska, Michael Amling, Marina Schorpp-Kistner, Peter Angel and Erwin F. Wagner
    Mice lacking JunB are osteopenic due to cell-autonomous osteoblast and osteoclast defects
    J of Cell Biology 2004, Volume 164, Number 4:613-623
  • Gong H, Zhang M, Yeung HY, Qin L.
    Regional variations in microstructural properties of vertebral trabeculae with ageing.
    J Bone Miner Metabol 23(2): (in print) 2004
  • Lee WTK, Cheung CSK, Tse YK, Guo X, Qin L, Ho SC, Lau J, Cheng JCY.
    Generalized low bone mass in adolescent idiopathic scoliosis is related to inadequate calcium intake and weight bearing physical activity in peripubertal period.
    Osteoporosis Int, 2004 (in print)
  • Yeung HY, Qin L, Lee SM, Zhang M, Leung KS, Cheng JCY.
    A novel approach for quantification of porosity for biomaterial implants using micro computed tomography (µCT).
    J Biomaterial Med Res, (in print) 2004
  • Day JS, van der Linden JC, Bank RA, Ding M, Hvid I, Sumner DR, Weinans H.
    Adaptation of subchondral bone in osteoarthritis.
    Biorheology 2004;41(3-4):359-68.
  • Day JS, Ding M, Bednarz P, van der Linden JC, Mashiba T, Hirano T, Johnston CC, Burr DB, Hvid I, Sumner DR, Weinans H.
    Bisphosphonate treatment affects trabecular bone apparent modulus through micro-architecture rather than matrix properties.
    J Orthop Res 2004; 22 (2004) 465-471.
  • Giesen EBW, Ding M, Dalstra M, van Eijden TMGJ.
    Changed morphology and mechanical properties of cancellous bone in the mandibular condyle of edentate people.
    J Dental Res 2004; 83(3):255-259.
  • Giesen EBW, Ding M, Dalstra M, van Eijden TMGJ.
    Architectural measures of the cancellous bone of the mandibular condyle identified by principal components analysis.
    Calcified Tissue Int 2003 73 (3): 225-231.
  • Ding M, Odgaard A, Hvid I.
    Changes in three-dimensional microstructure of human tibial early-stage osteoarthrotic cancellous bone.
    J Bone Joint Surg (Br) 2003; 85(6):906-12.
  • Ding M, Day JS, Burr DB, Mashiba T, Hirano T, Weinans H, Sumner DR, Hvid I.
    Canine trabecular architecture after one year of high dose bisphosphonates.
    Calcif Tissue Int 2003; 72 (6): 737-744.
  • Chi Hyun Kim, Erica Takai, Hua Zhou, Dietrich vib Stechow, Ralph Müller, David W Dempster, X Edward Guo
    Trabecular Bone Response to Mechanical and Parathyroid Hormone Stimulation: The Role of Mechanical Microenvironment
    JOURNAL OF BONE AND MINERAL RESEARCH, Volume 18, Number 12, 2003
  • N E Lane, W Yao, J H Kinney , G Modin, M Balooch, T J Wronsk
    Both hPTH(I-34) and BFGF Increase Trabecular Bone Mass in Osteopenic Rats but They Have Different Effects on Trabecular Bone Architecture
    JOURNAL OF BONE AND MINERAL RESEARCH Volume 18, Number 12, 2003
  • C. Schmidt, M. Priemel, T.Kohler, A.Weusten, R.Müller, M Amling and F.Eckstein
    Precision and Accuracy of Peripheral Quantitative Computed Tomography (pQCT) in the Mouse Skeleton compared with Histology and Microcompted Tomography (µCT)
    J Bone Miner Res 2003; 18: 11486-1496
  • Tamasi JA, Arey BJ, Bertolini DR, Feyen J HM
    Characterization of Bone Structure in Leptin-Deficient Zucker (fa/fa) Rats.
    J Bone and Mineral Res, Vol 18, No 9, 2003: 1605 -1611
  • Hu JH, Ding M, Søballe K, Bechtold JE, Danielsen CC, Day JS, Hvid I.
    Effects of short-term alendronate treatment on the three-dimensional microstructural, physical and mechanical properties of dog trabecular bone.
    Bone 2002; 31:591-597
  • Ding M, Odgaard A, Danielsen CC, Hvid I.
    Mutual associations among microstructural, physical and mechanical properties of human cancellous bone.
    J Bone Joint Surg (Br) 2002b; 84-B:900-907
  • Ding M, Odgaard A, Linde F, Hvid I.
    Age-related variations in the microstructure of human tibial cancellous bone.
    J Orthop Res 2002a; 20: 81-87
  • Veenland JF, Grashuis JL, Weinans H, Ding M, Vrooman HA.
    Suitability of texture features to assess changes in trabecular bone architecture.
    Pattern Recognition Letters 2002;23:395-403
  • N.L. Hill, A. Laib, M.K. Duncan
    Mutation of the ectodysplasin-a gene results in bone defects in mice.
    J Comp Pathol. 2002 Feb;126(2-3):220-225
  • P. Ammann, A. Laib, J.P. Bonjour, J.M. Meyer, P. Ruegsegger, R.Rizzoli
    Dietary essential amino acid supplements increase bone strength by influencing bone mass and bone microarchitecture in ovariectomized adult rats fed an isocaloric low-protein diet.
    J Bone Miner Res. 2002 Jul;17(7):1264-1272
  • Rüdiger Landers, Ute Hübner, Rainer Schmelzeisen, Rolf Mühlhaupt.
    Rapid prototyping of scaffolds derived from thermoreversible hydrogels and tailored for applications in tissue engineering.
    Biomaterials, 23:4437-4447, 2002
  • Babul Borah, Thomas E. Dufresne, Paula A. Chmielewski, Gary J. Gross, Marla C. Prenger and Roger J Phipps.
    Risedronate Preserves Trabecular Architecture and Increases Bone Strength in Vertebra of Ovariectomized Minipigs as Measured by Three-Dimensional Microcomputed Tomography.
    J. Bone Miner. Res., 17:1139:1147, 2002
  • Bernard P. Halloran, Virginia L. Ferguson, Steven J. Simske, Andrew Burghardt, Laura L. Venton and Sharmila Majumdar.
    Changes in Bone Structure and Mass With Advicing Age in the Male C57BL/6J Mouse.
    J. Bone Miner. Res., 17:1044-1050, 2002
  • D. Bikle, S. Majumdar, A. Laib, L. Powell-Braxton, C. Rosen, W. Beamer, E. Nauman, C. Leary, B. Halloran.
    The Skeletal Structure of Insulin-Like Factor-I Deficient Mice.
    J Bone Miner Res. 2001 Dec;16(12):2320-2329
  • Day JS, Ding M, van der Linden J, Hvid I, Sumner DR, Weinans H.
    A decreased subchondral trabecular bone tissue elastic modulus is associated with pre-arthritic cartilage damage.
    J Orthop Res 2001; 19:914-918
  • A. Laib, J.L. Kumer, S. Majumdar, N.E. Lane
    The Temporal Changes of Trabecular Architecture in Ovariectomized Rats Assessed by MicroCT.
    Osteoporos Int. 2001;12(11):936-941
  • SR. O. Cleveland, J. A. McAteer and R. Müller.
    Time-lapse non-destructive assessment of shock wave damage to kidney stones using micro-computed tomography.
    J. Acoust. Soc. Am., 110:1733-1736, 2001
  • SP. H. F. Nicholson, R. Müller, X. G. Cheng, P. Rüegsegger, G. Van der Perre, J. Dequeker and S. Boonen.
    Quantitative ultrasound and trabecular architecture in the human calcaneus.
    J. Bone Miner. Res., 16:1886-1892, 2001
  • SD. W. Dempster, F. Cosman, E. S. Kurland, H. Zhou, J. Nieves, L. Woelfert, E. Shane, K. Plavetic, R. Müller, J. Bilezikian and R. Lindsay.
    Effects of daily treatment with parathyroid hormone on bone microarchitecture and turnover in patients with osteoporosis: a paired biopsy study.
    J. Bone Miner. Res., 16:1846-1853, 2001
  • SJ. M. Alexander, I. Bab, S. Fish, R. Müller, T. Uchiyama, G. Gronowicz, M. Nahounou, Q. Zhao, D. W. White, M. Chorev, D. Gazit  and M. Rosenblatt.
    Human parathyroid hormone [hPTH-(1-34)] reverses bone loss in ovariectomized mice.
    J. Bone Miner. Res., 16:1665-1673, 2001
  • SG. Turgeman, D. Pittman, R. Müller, B. G. Kurkalli, S. Zhou, I. Moutsatsos, Y. Zilberman and D. Gazit.
    Engineered human mesenchymal stem cells: a novel platform for skeletal cell mediated gene therapy.
    J. Gene Med., 3:240-251, 2001
  • SR. Fajardo and R. Müller.
    Three-dimensional analysis of nonhuman primate trabecular architecture using micro-computed tomography.
    Am. J. Phys. Anthropol., 115:327-336, 2001
  • S. K. Boyd, N. Shrive, G. R. Wohl, R. Müller and R. F. Zernicke.
    Measurement of cancellous bone strain during mechanical tests using a new extensometer device.
    Med. Eng. Phys., 23:411-416, 2001
  • I. K. Moutsatsos, G. Turgeman, S. Zhou, B. G. Kurkalli, G. Pelled, L. Tzur, P. Kelley, N. Stumm, S. Mi, R. Müller, Y. Zilberman and D. Gazit.
    Exogenously regulated, stem cell mediated gene therapy for bone regeneration.
    Mol. Ther., 3:449-461, 2001
  • Peters O.A., Schönenberger K., Laib A.
    Effects of four Ni-Ti preparation techniques on root canal geometry assessed by micro computed tomography.
    Int Endod J, 34: 221-30, 2001
  • Peters O.A., Laib A., Göhring T.N., Barbakow F.
    Changes in root canal geometry after preparation assessed by high-resolution computed tomography.
    J Endod, 27:1-6, 2001

  • A. A. Kurth and R. Müller.
    The effect of an osteolytic tumor on three-dimensional trabecular bone morphology in an animal model.
    Skelet. Radiol., 30:94-98, 2001

  • C. H. Turner, Y. F. Hsieh, R. Müller, M. L. Bouxsein, C. J. Rosen, M. E. McCrann, L. R. Donahue and W. Beamer.
    Variation in bone biomechanical properties, microstructure and density in BXH recombinant inbred mice.
    J. Bone Miner. Res., 16:206-213, 2001

  • A. Laib, O. Barou, L. Vico, M.-H. Lafage-Proust, C. Alexandre, P. Rüegsegger
    3-D micro-computed tomography of trabecular and cortical bone architecture with application to a rat model of immobilization osteoporosis.
    Med Biol Eng Comp 38:326-332;2000

  • Day JS, Ding M, Odgaard A, Sumner DR, Hvid I, Weinans H.
    Parallel plate model for trabecular bone exhibits volume fraction-dependant bias.
    Bone 2000; 27:715-720.
  • Ding M, Hvid I.
    Quantification of age-related changes in the structure model type and trabecular thickness of human tibial cancellous.
    Bone 2000b; 26: 291-295.
  • H. Sasaki, L. Hou, A. Belani, T. Uchiyama, R. Müller and P. Stashenko.
    IL-10 but not IL-4 suppresses infection-stimulated bone resorption in vivo.
    J. Immunol., 65:3626-3630, 2000
  • A. Folch, S. Mezzour, M. Düring, O. Hurtado, M. Toner and R. Müller.
    Stacks of microfabricated structures as scaffolds for cell culture and tissue engineering.
    Biomedical Microdevices, 2:207-214, 2000

  • E. Cindik, M. Maurer, M. K. Hannan, R. Müller, W. C. Hayes, L. Hovy and A. A. Kurth.
    Phenotypical characterization of C-kit receptor deficient mouse femurs using non-destructive high-resolution imaging techniques and biomechanical testing.
    Technolgy and Health Care, 8:267-275, 2000

  • Peters O.A., Laib A., Rüegsegger P., Barbakow F.
    Three-dimensional analysis of root canal geometry using high-resolution computed tomography.
    J Dent Res, 79: 1405-9, 2000

  • Peters O.A., Göhring T.N, Laib A., Barbakow F.
    Darstellung der dreidimensionalen Geometrie von Wurzelkanälen mittels hochauflösender Computertomographie.
    Dtsch Zahnärztl Z, 55:184-7, 2000
  • M. Tantillo and R. Müller.
    Image-guided failure assessment of porous materials. In G. Baaklini, R. Gilmore, T. Matikas, N. Meyendorf, editors, Nondestructive Methods for Materials Characterization.
    Mat. Res. Soc., Vol. 591, pages 25-30, 2000
  • A. A. Kurth, S.-Z. Kim, F. Bauss, R. Müller and L.Hovy.
    Eine antiosteolytische Therapie bewahrt die Trabekelstruktur und die mechanischen Eigenschaften des Knochens in Tumorosteolysen.
    Z. Orthop., 138:146-151, 2000
  • S. K. Boyd, R. Müller, J. R. Matyas, G. R. Wohl and R. F. Zernicke.
    Early morphometric and anisotropic changes in periarticular cancellous bone in a model of experimental knee osteoarthritis quantified using micro-computed tomography.
    Clin. Biomech., 15:624-631, 2000

  • C. H. Turner, Y. F. Hsieh, R. Müller, M. L. Bouxsein, D. J. Baylink, C. J. Rosen, M. D. Grynpas, L. R. Donahue and W. Beamer.
    Genetic regulation of cortical and trabecular bone strength and microstructure in inbred strains of mice.
    J. Bone Miner. Res., 15:1126-1131, 2000
  • K. Balto, R. Müller, D. C. Carrington, J. Dobeck and P. Stashenko.
    Quantitation of periapical bone destruction in mice by micro-computed tomography.
    J. Dental Res., 79:35-40, 2000

  • Ding M.
    Age variations in the properties of human tibial trabecular bone and cartilage.
    Ph.D. Thesis, Aarhus University. 1999b. Acta Orthop Scand 2000a; 71: Supple 292:1-45
  • Ding M, Odgaard A, Hvid I.
    Accuracy of cancellous bone volume fraction measured by micro-CT scanning.
    J Biomech 1999a; 32:323-326
  • D. Ulrich, B. van Rietbergen, A. Laib, P. Rüegsegger.
    The ability of 3D structural indices to reflect mechanical aspects of trabecular bone.
    Bone 25(1):55- 60;199
  • B. Van Rietbergen, R. Müller, D. Ulrich, P. Rüegsegger and R. Huiskes.
    Tissue stresses and strain in trabeculae of canine proximal femur can be quantified from computer reconstructions.
    J. Biomech., 32:165-174, 1999
  • Maxine Gowen, Francesca lazner, Robert Dodds, Rasesh Kapadia, John Feild, Michael Tavaria, Ivan bertoncello, Fred Drake, Silva Zavarselk, Irene Tellis, Paul Hertzog, Christine Debouck and Ismail Kola
    Cathepsin K Knockout Mice Develop Osteopetrosis due to a Deficit in Matrix Degradation but not Mineralization
    J of Bone Min. Res. 14(10), 1999

  • A. Laib, P. Rüegsegger.
    Calibration of trabecular bone structure measurements of an in vivo 3D-pQCT with a micro CT.
    Bone 24(1):35-39;1999

  • A. Barbier, C. Martel, M.C. de Vernejoul, F. Tirode, M. Nys, G. Mocaer, C. Morieux, H. Murakami, F. Lacheretz
    The Visualization and Evaluation of Bone Architecture in the Rat using Three-dimensional X-Ray Microcomputed Tomography
    J bone Miner Metab 17:37-44, 1999

  • Technology and Health Care Special Issue
    Bone Architecture and the Competence of Bone
    Ed: Peter Rüegsegger, 1998

    • Rasesh D. Kapadia, George B. Struop, Alison M. Badger, Bruno Koller, Joshua M. Levin, Robert W. Coatney, Robert A. Dodds, Xiaguong Liang, Michael W. Lark, Maxine Gowen.
      Applications of Micro-CT and MR microscopy to study pre-clinical models of Osteoporosis and Osteoarthritis.

    • R. Müller, S. C. Gerber, W. C. Hayes
      Micro-compression: A novel technique for the nondestructive assessment of local bone failure.

    • F. Peyrin, M. Salome, P. Cloetens, AmM. Laval-Jeantet, E. Ritman, P. Rüegsegger
      Micro-CT Examinations of Trabecular Bone Samples at Different Resolutions: 14, 7 and 2 Micron Level

    • A. Laib, H.J. Häuselmann, P. Rüegsegger
      In Vivo High Resolution 3D-QCT of the Human Forearm

    • Thomas Dufresne
      Segmentation Techniques for Analysis of Bone by Three-Dimensional Computed Tomographic Imaging.

    • D. Ulrich, B. Rietbergen, A. Laib, P. Rüegsegger
      Mechanical Analysis of Bone and its Microarchitecture Based on In Vivo Voxel Images

    • B. van Rietbergen, S. Majumdar, W. Pistoia, D.C. Newitt, M. Kothari, A. Laib, P. Rüegsegger
      Assessment of Cancellous Bone Mechanical Properties from Micro-FE Models Based on Micro-CT, pQCT and MR Images

  • R. Müller, H. Van Campenhout, B. Van Damme, G. Van der Perre, J. Dequeker, T. Hildebrand, P. Rüegsegger
    Morphometric Analysis of Human Bone Biopsies: A Quantitative Structural Comparison of Histological Sections and Micro-Computed Tomography.
    Bone 23:59-66, 1998

  • M. Mullender, B. van Rietbergen, P. Rüegsegger, R. Huiskes
    Effect of Mechanical Set Point of Bone Cells on Mechanical Control of Trabecular Bone Architecture.
    Bone 22:125-131, 1998

  • T. Hildebrand, A. Laib, D. Ulrich, A. Kohlbrenner, P. Rüegsegger
    Bone Structure as Revealed by Microtomography.
    Proceedings of SPIE 3149:34-43, 1997

  • D. Ulrich, B. Van Rietbergen, A. Laib, P. Rüegsegger
    Bone Density and Microstructure - New Methods to Determine Bone Quality and Fracture Risk.
    In: Computer Methods in Biomechanics & Biomedical Engineering. Ed. J. Middleton, Gordon & Breach, 1997

  • D. Ulrich, T. Hildebrand, B. VanRietbergen, R. Müller, P. Rüegsegger
    The quality of trabecular bone evaluated with micro-computed tomography, FEA and mechanical testing.
    In: Bone Research in Biomechanics. Ed.: G. Lowet et. al. IOS Press Amsterdam, 97-112, 1997

  • R. Müller, P. Rüegsegger
    Micro-tomographic imaging for the nondestructive evaluation of trabecular bone architecture.
    In: Bone Research in Biomechanics. Ed.: G. Lowet et. al. IOS Press Amsterdam, 61-80, 1997

  • A. Laib, T. Hildebrand, H.J. Häuselmann, P. Rüegsegger
    Ridge Number Density:A New Parameter for in vivo Bone Structure Analysis.
    Bone 21:541-546, 1997

  • R. Müller, T. Hildebrand and P. Rüegsegger
    Structural properties of trabecular bone from different sites of the human skeleton: a descriptive study.
    Trans. Europ. Orthop. Res. Soc., 7:275, 1997

  • T. Hildebrand, P. Rüegsegger
    Quantification of Bone Microarchitecture with the Structure Model Index.
    Computer Methods in Biomechanics and Biomedical Engineering 1:15-23, 1997.

  • R. Müller, S. Matter, P. Neuenschwander, U.W. Suter, P. Rüegsegger
    3D Micro Tomographic Imaging and Quantitative Morphometry for the Nondestructive Evaluation of Porous Biomaterials.
    In: R. Briber, D.G. Pfeiffer, C.C. Han, editors, Morphological Control in Multiphase Polymer Mixtures. Mat.Res.Soc.Proc. 461:217-222, 1997

  • J. Reeve, H. Krüger, P. Rüegsegger, J. Dequeker
    Radial Cortical and Trabecular Bone Densities of Men and Women Standardized with the EFP.
    Calcif Tissue Int 58:135-143, 1996

  • R. Müller, M. Hahn, M. Vogel, G. Delling, P. Rüegsegger
    Morphometric analysis of noninvasively asessed bone biopsies: Comparison of high-resolution CT and histologic sections.
    Bone 18:215-220, 1996

  • R. Müller, P. Rüegsegger
    Analysis of mechanical properties of cancellous bone under conditions of simulated bone atrophy.
    J Biomechanics 29:1053-1060, 1996

  • R. Müller, B. Koller, T. Hildebrand, A. Laib, S. Gianolini and P. Rüegsegger
    Resolution dependency of microstructural properties of cancellous bone based on three-dimensional µ-tomography.
    Technology and Health Care, 4:113-119, 1996

  • T. Hildebrand and P. Rüegsegger
    A new method for the model-independent assessment of thickness in three-dimensional images.
    Journal of Microscopy, 185:67-75, 1996

  • P. Rüegsegger, B. Koller and R. Müller
    A microtomographic system for the nondestructive evaluation of bone architecture.
    Calcif. Tiss. Int., 58:24-29, 1996

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